What Did Dr. Lee Cover at an Early Meeting

Dr. Andrew Lee spoke at the support group meeting on Wed. Jan 23rd. Over 30 persons were in attendance. Several “graduates” attended. Dr. Lee responded to several questions that had been submitted, and took an equal number of questions from the floor.

Here were my “keepers” from the meeting. If you have additional items please post them here as a comment to this note or let me know and I’ll circulate to the newsletter mailing list.

1) After 18 months of operation the proton therapy as delivered by Anderson Proton Center is being well tolerated and results are above the expectations of the medical team. It’s still much too early to publish results but Dr. Lee is optimistic and expecting that the results will be better than what’s been previously published. Two key factors that are driving this improvement are 1) the control over targeted tumor area is more precise, and 2) the dosage is higher than used a few years ago.
2) “Graduates” were cautioned that care should be taken in having a colonoscopy and Dr. Lee recommended that we wait a year after completion of treatment. Since proton therapy is relatively new, and not many colonoscopists are versed in the therapy, some of their actions may cause inadvertent injury to the rectum as they take biopsies. If you have any questions please contact Dr. Lee or Dr. Choi.

3) There was considerable amount of discussion over PSA results. Summarizing as best I can without having had Dr. Lee review these notes here’s what I heard. The PSA nadir (lowest reading) is reached on average around 18 months after completion of treatment. There is no absolute number that one should look for after treatment and having a high PSA (called PSA failure) is not specific to cancer. There are many things that will cause PSA readings to increase like manipulation during an examination, inflammation, bacterial prostatitis, urinary retention, exercise like riding a bike, and ejaculation. ( there is an article in this web blog about activities you should avoid before having your PSA tested, including a DRE as some urologists have done prior to drawing blood).


4) New PSA serum tests. The current PSA test was developed as a screening tool but now also commonly used to track patient recovery. It’s not necessarily a marker to cancer and more specific serum markers tests like EPCA and EPCA-2 developed at John Hopkins are waiting for FDA approval. The method is not proven and much testing remains to be done. Quoting Dr. Patrick Walsh, “EPCA-2 could help determine which men with abnormal PSA levels have prostate cancer. But it’s possible that EPCA-2 may even replace PSA one day as the screening test of choice.”


5) There were quite a few questions the hormone therapy but I don’t have the specifics to report.

6) The therapy(pencil beam or spot scattering) for the 3rd gantry was been recently approved by the FDA and the equipment is being commissioned for clinical use and will be used starting this summer. Hitachi, the equipment manufacturer for the M.D. Anderson Proton Therapy Center received the approval and will undoubtedly implement this therapy in other locations, however I believe that 3rd gantry was where it was developed and the tested.